← Back to research topics
II / Fidelity · Accurate inheritance · 05
Chromosome shaping & segregation
Why does chromosome shape matter for accurate segregation?
01 / The Central Question
Chromosomes contain long DNA molecules that must be carefully packed. Their shape affects whether the two new cells can each receive the correct genetic information.
When chromosomes are not organized or separated correctly, a daughter cell can receive the wrong number of chromosomes. Such chromosome-number abnormalities are also common in cancer cells.
02 / Mechanisms & Discoveries
How these processes work
Choose a question below to read how the process works, what research has shown and which questions remain open. Each explanation also links to the original papers and press releases.
01 / 03How chromosome shape affects separationWhy does the shape of a chromosome change how easily it separates?Read the explanation02 / 03Folding long DNA into chromosomes that can separateHow do cells compact long DNA without preventing its separation?Read the explanation03 / 03From local DNA folding to the shape of a chromosomeHow do changes in small DNA packages influence whole chromosomes?Read the explanation