Collective molecular organization & cellular remodeling
How do collective protein assemblies reshape cellular structure and function?
Proteins can gather into large, dynamic assemblies. Some flow like liquid droplets; others become more gel-like or generate local pressure. We study how these collective effects change the shape and function of cells.
Changes in how proteins gather can disrupt the disposal of unwanted material or alter cell shape. Understanding these physical changes may offer clues to cellular abnormalities associated with disease, although the studies here do not by themselves establish a cause of a particular disorder.
What happens when proteins gather
Choose a question below to read how the process works, what research has shown and which questions remain open. Each explanation also links to the original papers and press releases.